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. 2022 Mar 14;12(6):2860–2893. doi: 10.7150/thno.70721

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CDs-based cancer therapy by DNA nanostructure. (A) The chemical route to synthesize NCDs. (B) NCDs-assisted DNA NP self-assembly. (C) Cellular uptake evaluation of NP^NCD on KRAS-mutated NSCLC cell lines and CLSM imaging of NP^NCD internalized by A549 and H23. (D) The formation of NP^NCD showed by PAGE. (E) Self-assembly of NP^NCD at various NCDs concentration. (F) NCDs-induced isothermal DNA NP self-assembly and corresponding formation of DNA NP at different temperature. (G) PAGE analysis of NP^NCD formation under different pH values. (H) PAGE electrophoresis showing the serum stability of NP^NCD and magnesium-assembled NP (NP^Mg). (I) PAGE analysis of the formation of CDs/NP conjugating with KRAS siRNA. Adapted with permission from ²³⁵, copyright 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.