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. 2022 Mar 15;10:819967. doi: 10.3389/fcell.2022.819967

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Copyright © 2022 Bauch, Ort, Ulc and Faissner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A,B) Comparative analysis of Olig2/473HD-staining in the corpus callosum of SV129, Tnc ^−/−, and Tnr ^−/− mice under control, demyelinated, and remyelinated conditions. Immunohistochemical labeling (A) with antibodies against Olig2 (detects all oligodendroglia) and 473HD (detects chondroitin sulfate) of SV129, Tnc ^−/−, and Tnr ^−/− brain sections under different conditions (control, demyelinated, one-week remyelinated, two-weeks remyelinated) is shown. (B) Quantitative analysis of the 473HD fluorescence intensity (CTCF) in the corpus callosum above the region of the hippocampus. The fluorescence intensity was significantly reduced within the corpus callosum of Tnr ^−/− in control and demyelinated conditions. DAPI stains cell nuclei in blue. Scale bar: illustration: 100 μm, detail pictures: 50 µm. N = 3 animals were used for each group and genotype, and at least n = 500 cells were evaluated for each individual animal.