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. 2022 Mar 30;12:5375. doi: 10.1038/s41598-022-09306-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Human liver organoid cells expressed markers of cholangiocyte and hepatoblast. Characterisation of human liver organoids. (A(i)) UMAP showing the assigned identity for each cluster (3 clusters) in 10X Genomics single-cell RNA sequencing analysis of human control liver organoids. (A(ii)) Heatmap of top 10 markers expressed for each clusters in HB control organoids at p < 0.05. (A(iii)) Dot plot showing expression of canonical markers used for identification of clusters including cytokeratin-19 (KRT19) and epithelial cellular adhesion molecule (EPCAM). (B) Violin plots showing levels of expression of canonical markers for cholangiocytes and hepatoblast used for classification of cell types in control liver organoids. (C) Immunofluorescence staining for KRT19 of human control liver organoids.