TABLE 2.
Drugs involved in drug-induced liver injury.
| case | Drugs | RUCAM score | LTT (SI) | No. of drugs | No. of positive LTTs |
|---|---|---|---|---|---|
| 1 | Fosfomycin | 7 | 1.30 | 2 | 0 |
| Ciprofloxacin | 9 | 1.80 | |||
| 2 | Ceftriaxone | 5 | 1.40 | 2 | 1 |
| Piperacillin/Tazobactam | 5 | 2.30 | |||
| 3 | Acetylsalicylic acid | 5 | 0.80 | 6 | 2 |
| Amoxicillin | 6 | 0.60 | |||
| Azathioprine | 7 | 0.80 | |||
| Clarithromycin | 6 | 1.10 | |||
| Metamizole | 4 | 2.00 | |||
| Nitroglycerine | 4 | 2.40 | |||
| 4 | Cefditoren | 5 | 4.10 | 3 | 2 |
| Ezetimibe | 8 | 3.50 | |||
| Atorvastatin | 4 | 1.10 | |||
| 5 | Amoxicillin | 7 | 3.00 | 3 | 1 |
| Acetaminophen | 7 | 0.60 | |||
| Metamizole | 6 | 0.70 | |||
| 6 | Amoxicillin | 10 | 16.50 | 2 | 1 |
| Levofloxacin | 5 | 1.00 | |||
| 7 | Amoxicillin | 7 | 1.50 | 3 | 0 |
| Ibuprofen | 7 | 1.00 | |||
| Acetaminophen | 7 | 1.00 | |||
| 8 | Omeprazole | 7 | 0.40 | 4 | 1 |
| Escitalopram | 7 | 3.70 | |||
| Ciprofloxacin | 7 | 0.40 | |||
| Amoxicillin | 7 | 0.40 | |||
| 9 | Clomipramine | 9 | 2.30 | 4 | 2 |
| Trazodone | 6 | 1.60 | |||
| Venlafaxine | 10 | 4.00 | |||
| Vortioxetine | 7 | 0.50 | |||
| 10 | Amoxicillin | 6 | 1.00 | 9 | 2 |
| Cefazolin | 6 | 1.00 | |||
| Dexketoprofen | 6 | 0.80 | |||
| Indomethacin | 6 | 1.20 | |||
| Ibuprofen | 5 | 0.70 | |||
| Lidocaine | 3 | 0.70 | |||
| Mepivacaine | 4 | 2.00 | |||
| Metamizole | 6 | 0.80 | |||
| Acetaminophen | 5 | 0.90 | |||
| 11 | Labetalol | 7 | 0.40 | 3 | 2 |
| Amlodipine | 4 | 2.80 | |||
| Methyldopa | 6 | 3.00 | |||
| 12 | Pyrazinamide | 6 | 4.20 | 2 | 1 |
| Rifampicin | 3 | 1.30 | |||
| 13 | Pyrazinamide | 8 | 5.10 | 2 | 2 |
| Rifampicin | 3 | 2.50 | |||
| 14 | Isoniazid | 9 | 3.20 | 1 | 1 |
| 15 | Amoxicillin | 6 | 1.20 | 3 | 0 |
| Ibuprofen | 7 | 0.40 | |||
| Acetaminophen | 7 | 0.60 | |||
| 16 | Dexketoprofen | 6 | 1.20 | 5 | 1 |
| Levofloxacin | 6 | 1.50 | |||
| Amikacin | 4 | 2.20 | |||
| Metamizole | 4 | 1.502 | |||
| Acetaminophen | 4 | 1.603 | |||
| 17 | Levofloxacin | 7 | 1.100 | 5 | 0 |
| Piperacillin/Tazobactam | 7 | 1.200 | |||
| Clarithromycin | 6 | 1.101 | |||
| Ceftriaxone | 6 | 1.301 | |||
| Dexketoprofen | 6 | 1.100 | |||
| 18 | Cefazolin | 7 | 0.901 | 5 | 2 |
| Quetiapine | 7 | 4.301 | |||
| Tramadol | 6 | 1.502 | |||
| Sulfamethoxazole | 6 | 5.80 | |||
| Ferrous gluconate | 6 | 1.70 | |||
| 19 | Diazepam | 3 | 30.30 | 4 | 3 |
| Acetaminophen | 3 | 2.50 | |||
| Dexketoprofen | 3 | 6.00 | |||
| Sulpiride | 3 | 1.30 | |||
| 20 | Meropenem | 4 | 1.30 | 1 | 0 |
| 21 | Acetaminophen | 5 | 1.70 | 2 | 0 |
| Ibuprofen | 5 | 1.20 | |||
| 22 | Praziquantel | 6 | 1.30 | 5 | 1 |
| Rifampicin | 6 | 1.30 | |||
| Cloxacillin | 6 | 1.00 | |||
| Cefepime | 6 | 0.60 | |||
| Vancomycin | 5 | 2.60 | |||
| 23 | Amoxicillin | 8 | 11.20 | 2 | 1 |
| Ezetimibe | 4 | 1.50 | |||
| 24 | Amoxicillin | 3 | 1.30 | 3 | 0 |
| Piperacillin/Tazobactam | 3 | 0.60 | |||
| Levetiracetam | 3 | 0.60 | |||
| 25 | Lopinavir/ritonavir | 4 | 3.20 | 1 | 1 |
| 26 | Azithromycin | 7 | 1.60 | 6 | 1 |
| Tocilizumab | 7 | 1.30 | |||
| Hydroxychloroquine | 7 | 1.60 | |||
| Lorazepam | 5 | 2.40 | |||
| Acetaminophen | 4 | 1.10 | |||
| Metamizole | 4 | 2.00 | |||
| 27 | Hydroxychloroquine | 7 | 3.00 | 6 | 2 |
| Ceftriaxone | 6 | 1.80 | |||
| Azithromycin | 7 | 1.80 | |||
| Lopinavir/ritonavir | 7 | 1.20 | |||
| Pantoprazole | 6 | 2.80 | |||
| Ciprofloxacin | 6 | 2.00 | |||
| 28 | Metamizole | 6 | 1.40 | 4 | 1 |
| Tramadol | 6 | 1.40 | |||
| Atorvastatin | 8 | 11.20 | |||
| Diosmin | 6 | 1.30 | |||
| 29 | Dexketoprofen | 5 | 0.90 | 1 | 0 |
| 30 | Lopinavir/ritonavir | 4 | 1.70 | 5 | 1 |
| Levofloxacin | 4 | 2.30 | |||
| Dexketoprofen | 4 | 1.50 | |||
| Interferon beta | 4 | 1.80 | |||
| Hydroxychloroquine | 4 | 1.90 | |||
| 31 | Tocilizumab | 7 | 2.30 | 2 | 1 |
| Hydroxychloroquine | 7 | 1.50 | |||
| 32 | Dexketoprofen | 8 | 2.60 | 5 | 2 |
| Acetaminophen | 5 | 2.201 | |||
| Metamizole | 5 | 1.702 | |||
| Ibuprofen | 8 | 1.90 | |||
| Omeprazole | 8 | 1.90 | |||
| 33 | Azithromycin | 6 | 4.30 | 1 | 1 |
| 34 | Amoxicillin | 5 | 5.00 | 4 | 2 |
| Ibuprofen | 5 | 1.90 | |||
| Methocarbamol | 5 | 15.80 | |||
| Metamizole | 3 | 0.70 | |||
| 35 | Ceftriaxone | 6 | 0.70 | 2 | 0 |
| Acetaminophen | 6 | 0.80 | |||
| 36 | Olanzapine | 4 | 2.90 | 2 | 2 |
| Quetiapine | 4 | 2.50 | |||
| 37 | Hydroxychloroquine | 4 | 1.70 | 6 | 2 |
| Azithromycin | 4 | 3.80 | |||
| Dexketoprofen | 4 | 2.80 | |||
| Doxycycline | 4 | 0.70 | |||
| Omeprazole | 4 | 1.80 | |||
| Enoxaparin | 4 | 1.60 | |||
| 38 | Atorvastatin | 7 | 4.40 | 5 | 1 |
| Enoxaparin | 7 | 0.70 | |||
| Metamizole | 6 | 0.70 | |||
| Metoclopramide | 4 | 0.50 | |||
| Acetaminophen | 8 | 0.90 | |||
| 39 | Ceftriaxone | 5 | 2.20 | 1 | 1 |
| 40 | Amoxicillin | 8 | 1.50 | 5 | 1 |
| Acetaminophen | 8 | 1.40 | |||
| Metamizole | 8 | 1.30 | |||
| Enoxaparin | 8 | 3.10 | |||
| Omeprazole | 8 | 1.20 | |||
| 41 | Acetaminophen | 9 | 1.80 | 4 | 0 |
| Bemiparin | 8 | 1.90 | |||
| Acetylsalicylic acid | 5 | 1.00 | |||
| Paricalcitol | 3 | 0.70 | |||
| 42 | Valaciclovir | 10 | 1.00 | 3 | 0 |
| Ibuprofen | 5 | 0.70 | |||
| Berberine | 3 | 0.60 | |||
| 43 | Ceftriaxone | 5 | 1.80 | 3 | 1 |
| Dexketoprofen | 5 | 4.00 | |||
| Acetaminophen | 3 | 1.70 | |||
| 44 | Atorvastatin | 8 | 2.20 | 1 | 1 |
| 45 | Cefuroxime | 6 | 2.50 | 1 | 1 |
Abbreviations: LTT, lymphocyte transformation test; RUCAM, roussel uclaf causality assessment method; SI, stimulation index.