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. 2022 Mar 10;13:849628. doi: 10.3389/fphar.2022.849628

FIGURE 1.

FIGURE 1

Mechanism of action of aspirin. Aspirin possesses several targets through which it exerts its activity. First, it inhibits prostanoids synthesis thus employing anti-thrombotic, anti-inflammatory, anti-pyretic and analgesic effect. In addition, it acetylates multiple cellular proteins hence affecting DNA transcription and expression. It also constrains NF-KB production, limiting its pro-inflammatory effect. Furthermore, aspirin enhances the synthesis of eicosanoids and 15-epi-lipoxin A4. Combining all together, aspirin impedes PMNs interaction with platelets and endothelium, PMNs chemotaxis, adhesion, and migration. Finally, it acetylates and activates eNOS to maintain vascular homeostasis. (NF-KB: nuclear factor kappa B; PMNs: polymorphonuclear cells; eNOS endothelial nitric oxide synthase).