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. 2022 Mar 15;13:852674. doi: 10.3389/fphys.2022.852674

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Copyright © 2022 Lo, Forst, Warth and Zdebik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural model of the Kir4.1/Kir5.1 heteromer (rendered with PyMol 2.5.2) of a Kir4.1/Kir5.1 model generated with AlphaFold Multimer (Jumper et al., 2021, Evans and O’Neill, https://www.biorxiv.org/content/10.1101/2021.10.04.463034v1). We truncated both N- and C-termini slightly, to reduce complexity. AlphaFold yielded three models with almost identical ranking, but only one of them conformed to the alternating subunit structure postulated by Lagrutta et al. (1996). Kir4.1 subunits are brown, and Kir5.1 subunits are green.