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Localization of disease-associated mutations in human Kir4.1 (A) and Kir5.1 (B). Functional consequences of Kir5.1 mutations were determined by coexpression with Kir4.1. Please note that functional deficits were more pronounced when Kir5.1 was coexpressed with Kir4.2 (Schlingmann et al., 2021; Neubauer et al., 2022). For more detailed information see Tables 1 and 2.
