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KCF18 reduces the production of cytokine-induced ROS in macrophages. ROS production induced by TNF-α (A), IL-1β (B), and IL-6 (C) was detected as described in the Materials and Methods section. Values are the mean ± SD of fluorescent intensities versus control from three independent experiments. **p < 0.01 versus control and #p < 0.05, ##p < 0.01 versus cells stimulated with cytokines in the presence of KCF18.
