Table 2. Risk of Disabling Dementia Risk According to Physical Activity in Men and Women.
| Physical activity | Men | Women | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | P for trend | Q1 | Q2 | Q3 | Q4 | P for trend | |
| Daily total physical activity | ||||||||||
| MET-h/d, median (range) | 29.6 (22.4-32.1) | 34.5 (32.1-37.5) | 42.5 (37.6-49.0) | 59.7 (49.0-92.5) | NA | 29.9 (21.8-32.3) | 34.5 (32.3-36.8) | 39.8 (36.8-44.6) | 52.9 (44.6-93.4) | NA |
| Person-years, No. | 43 881 | 48 021 | 48 277 | 47 913 | NA | 53 221 | 57 776 | 58 623 | 59 314 | NA |
| Incident dementia, No. | 780 | 452 | 439 | 422 | NA | 1226 | 687 | 542 | 462 | NA |
| Model 1 HR (95% CI)a | 1 [Reference] | 0.71 (0.63-0.80) | 0.67 (0.60-0.76) | 0.73 (0.65-0.83) | <.001 | 1 [Reference] | 0.75 (0.68-0.83) | 0.71 (0.64-0.79) | 0.72 (0.64-0.80) | <.001 |
| Model 1 HR (95% CI)b | 1 [Reference] | 0.73 (0.65-0.82) | 0.69 (0.61-0.78) | 0.75 (0.66-0.85) | <.001 | 1 [Reference] | 0.76 (0.69-0.84) | 0.73 (0.66-0.81) | 0.75 (0.67-0.84) | <.001 |
| Daily total MVPA | ||||||||||
| MET-h/d, median (range) | 0.4 (0-3.2) | 6.0 (2.5-9.0) | 16.7 (9.0-19.0) | 42.0 (25.5-111.0) | NA | 0.3 (0-2.5) | 6.0 (2.5-9.0) | 12.1 (9.0-19.0) | 30.8 (19.1-108.0) | NA |
| Person-years, No. | 44 019 | 48 076 | 48 147 | 47 852 | NA | 53 857 | 51 337 | 64 391 | 59 350 | NA |
| Incident dementia, No. | 768 | 449 | 455 | 421 | NA | 1152 | 650 | 655 | 460 | NA |
| Model 1 HR (95% CI)a | 1 [Reference] | 0.72 (0.64-0.80) | 0.65 (0.58-0.73) | 0.72 (0.64-0.82) | <.001 | 1 [Reference] | 0.81 (0.73-0.89) | 0.74 (0.68-0.82) | 0.71 (0.64-0.80) | <.001 |
| Model 2 HR (95% CI)b | 1 [Reference] | 0.73 (0.65-0.82) | 0.66 (0.59-0.74) | 0.74 (0.65-0.84) | <.001 | 1 [Reference] | 0.82 (0.74-0.91) | 0.77 (0.69-0.85) | 0.74 (0.66-0.83) | <.001 |
| Leisure-time MVPA | ||||||||||
| MET-h/d, median (range) | 0 | 0.1 (0.03-0.3) | 0.9 (0.3-1.6) | 3.8 (1.6-58.5) | NA | 0 | 0.1 (0.03-0.3) | 0.8 (0.3-1.7) | 3.8 (1.7-58.5) | NA |
| Person-years, No. | 54 214 | 46 444 | 43 611 | 43 825 | NA | 76 689 | 50 942 | 49 662 | 51 642 | NA |
| Incident dementia, No. | 930 | 443 | 307 | 413 | NA | 1420 | 540 | 451 | 506 | NA |
| Model 1 HR (95% CI)a | 1 [Reference] | 0.89 (0.79-1.00) | 0.64 (0.56-0.73) | 0.60 (0.53-0.67) | <.001 | 1 [Reference] | 0.92 (0.83-1.02) | 0.75 (0.67-0.83) | 0.69 (0.62-0.76) | <.001 |
| Model 2 HR (95% CI)b | 1 [Reference] | 0.90 (0.80-1.01) | 0.65 (0.57-0.74) | 0.59 (0.53-0.67) | <.001 | 1 [Reference] | 0.94 (0.85-1.05) | 0.76 (0.68-0.85) | 0.70 (0.63-0.78) | <.001 |
Abbreviations: HR, hazard ratio; MET, metabolic equivalent; MVPA, moderate to vigorous physical activity; NA, not applicable; Q, quartile.
a
Adjusted for age and area.
b
Additionally adjusted for smoking status (never, former, 1-19 cigarettes/d, or ≥20 cigarettes/d), alcohol intake status (none or occasional drinkers, 1 to <150 g/week, 150 to <300 g/week, or ≥300 g/week), body mass index (calculated as weight in kilograms divided by height in meters squared; <18.5, 18.5-24.9, 25-29, or ≥30), past history of diabetes (yes or no), medication for hypertension (yes or no), and occupation (primary industry, secondary or tertiary industry, unemployed, or household duties).