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. 2022 Jan 24;71(4):853–861. doi: 10.2337/db21-0704

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© 2022 by the American Diabetes Association

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CMTN genes targeted by the T2D-associated miRNAs and their association with T2D. A: T2D miRNAs and their target CMTN genes, with a focus on genes related to cholesterol efflux, uptake, and synthesis. miRNAs and their target genes that were increased in T2D are colored pink, while miRNAs and their target genes that were decreased in T2D are colored blue. Greater miRNA expression is predicted to lead to decreased expression of its target genes, and lesser miRNA expression is predicted to lead to increased expression of its target genes. Therefore, the effects of miRNAs with decreased expression on their downstream gene targets are indicated with a short dashed line and an X. MYLIP encodes IDOL, which leads to degradation of the LDL receptor through its ubiquitin ligase activity. The activating effect of decreased MYLIP expression on the LDL receptor is indicated by the long dashed line and an X. B: Results of the differential gene expression analysis of the T2D-associated miRNA target genes by T2D status.