TABLE 1.
Pharmacokinetics of aciclovir
| Parameter | Median value (95% CI)
|
||
|---|---|---|---|
| Intravenous aciclovir (400 mg) | Oral aciclovir (400 mg) | Oral valaciclovir (500 mg) | |
| AUC (μmol · h/liter) | 89.7 (73.0–117.5) | 19.7 (15.6–27.5) | 49.7 (41.1–67.3) |
| Cmax (μmol/liter) | 41.6 (33.6–52.3) | 2.5 (2.1–3.1) | 12.0 (8.5–16.5) |
| Tmax (h) | 1.0 (end of infusion) | 2.4 (1.4–4.3) | 2.5 (1.5–3.4) |
| t1/2 (h)a | 2.3 (2.0–2.7) | 3.7 (3.1–5.0) | 2.1 (1.7–2.7) |
| Cmax/AUC | 0.14 (0.11–0.16) | 0.23 (0.20–0.26) | |
| Bioavailability (%) | 21.5 (17.9–33.2) | 70.1 (58.5–78.4) | |
a
t1/2, half-life.