Figure 5.

Immunoblot analysis of adipogenic markers in the hearts of Cov2 infected, T. cruzi infected, and coinfected huACE2 mice. Western blot images of (A) cardiac high-molecular weight adiponectin (HMW ApN) and (B) ApN receptors (Adipo R1, R2 and T-cadherin). β-Actin was used as loading control. Fold-changes in the protein levels of adipogenic markers normalized to β-Actin are shown as bar graphs. (A dot plot displaying individual data point is shown in Supplementary Figure 4). The error bars represent standard error of the mean. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 compared to uninfected sex matched mice (n = 4/sex/group) (^##p ≤ 0.01 for comparisons between CoV2 infected and coinfected mice) (M, male; F, female).