Figure 1.

The early stage of sepsis is often accompanied by an acute phase of SAE characterized by delirium symptoms and acute changes in the patient's consciousness. In addition, in the late stage of sepsis, more than half of surviving patients gradually progress to the chronic phase of SAE suffering from severe and long-term cognitive deficits, and even depression, anxiety, post-traumatic stress disorder, and self-destructive tendencies, that affect their daily quality of life and place a significant burden on families and society.