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. 2022 Mar 16;13:830784. doi: 10.3389/fneur.2022.830784

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Copyright © 2022 Gao, Liu, Zhang, Shou and Chai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mechanisms of Regulatory T cells (T_regs) in sepsis-associated encephalopathy (SAE). Several studies evidence the mechanisms by which T_regs may affect different processes know to be related with SAE pathophysiology. The latter include suppression of systemic immune-inflammation/cytokine storm, resolution of excessive neuroinflammation and ischemic processes/injury, regulate the imbalance of neurotransmitters and regulation of glial cells and cerebral endothelial cells (CECs) activity.