FIGURE 1.

(A) T1-weighted axial and (B) sagittal image of sibling one performed at 9 years of age show diffuse cerebral, cerebellar and brain stem atrophy and relatively normal ventricle. (C)T1-weighted axial and (D) sagittal image of sibling one performed at 18 years were not changed significantly. (E)T1-weighted axial and (F) sagittal image of sibling two performed at 4 years of age show diffuse cerebral, cerebellar and brain stem atrophy and mild hydrocephalus. (G)T1-weighted axial and (H) sagittal image of sibling two performed at 16 years were not changed significantly.