Table 1.
Baseline features in the whole group and comparison between MCI− and MCI+.
| SCD | MCI− | MCI+ | |
|---|---|---|---|
| N [% (95% C.I.)] | 54 | 40 [74.07 (62.39–85.76)] | 14 (25.93 [14.24–37.61]) |
| Age at baseline, mean (SD) | 60.80 (7.33) | 59.99 (7.63) | 63.11 (6.073) |
| Age at onset, mean (SD) | 56.13 (9.09) | 54.73 (9.67) | 60.14 (5.75) |
| Disease duration, median (IQR) | 3.33 (5.09) | 3.58 (4.02) | 2.72 (1.30) |
| Follow-up time, median (IQR) | 15.29 (4.67) | 15.29 (4.44)*** | 8.35 (6.33)*** |
| Sex (women/men) | 37/13 | 26/14 | 11/3 |
| Family history of dementia, % (95% C.I.) | 51.85% (38.52–65.18) | 52.50% (37.02–67.98) | 50.00% (23.81–76.19) |
| Years of education, median (IQR) | 12.50 (8) | 12.58 (4.41) | 11 (5.97) |
| TIB, median (IQR) | 113.09 (4.57) | 113.11 (4.49) | 113.04 (20.29) |
| CAG repeat (shorter allele), median(IQR) | 18.00 (4) | 18.00 (4) | 17.50 (4) |
| CAG repeat (longer allele), median(IQR) | 21.00 (4) | 21.00 (4) | 19.50 (7) |
| APOE ε4+, % (95% C.I.) | 31.71% (17.46–45.95) | 17.50% (5.72–29.28) | 42.86% (16.93–68.78) |
| IA+ % (95% C.I.) | 11.11% (2.73–19.49) | 66.67% (28.95–104.39) | 33.33% (−4.39–71.05) |
| MMSE, median (IQR) | 29.00 (1) | 30.00 (1) | 29.00 (1) |
| HDRS, median (IQR) | 25.00 (6.00) | 25.00 (6.00) | 26.50 (7.75) |
| MAC-Q, mean (SD) | 25.84 (2.57) | 25.84 (2.54) | 25.81 (2.79) |
| Energy, mean (SD) | 45.50 (10.24) | 46.55 (10.42) | 42.50 (9.42) |
| Friendship, mean (SD) | 49.80 (9.12) | 48.80 (9.27) | 52.64 (8.33) |
| Conscientiousness, mean (SD) | 46.83 (9.86) | 45.75 (10.24) | 49.93 (8.23) |
| Emotional Stability, mean (SD) | 49.28 (10.52) | 48.05 (10.04) | 52.79 (11.45) |
| Openness, mean (SD) | 46.91 (10.41) | 47.20 (10.34) | 46.07 (10.80) |
Demographic data. Values quoted in the table are mean (SD), median (IQR), percentages (95% C.I.), or frequencies. Age at baseline, age at onset, follow-up time, disease duration are expressed in years. Statistical significance received a Bonferroni adjustment and being accepted at the p < 0.003 and p < 0.016 for categorical variables
(***p < 0.001, η2 = 0.27).
TIB: MMSE, Mini Mental State Examination; HDRS, Hamilton Depression Rating Scale; MAC-Q, Memory Assessment Clinics-Questionnaire.