Fig. 6.

Cargo eliminated GBM-sEVs as efficient drug vehicles in immunocompetent orthotopic brain tumor model. (A) Experimental design of the orthotopic tumor model. (B) Images of the orthotopic brain tumor model collected after treatment (upper), the tumors were pointed with green arrows. The tumor was detected by HE staining (lower). (C) Statistical analysis of the tumor volumes. (D) The fluorescence images of DOX in the brain of three groups (control group, DOX group and GL261-sEVs-DOX group) detected by confocal microscopy (upper). The statistical analysis was listed on the right. (E) The fluorescence images of DOX in normal brain region and tumor region of GL261-sEVs-DOX group, and the statistical analysis was listed on the right. (F) Kaplan-Meier analysis of the survival time of orthotopic brain tumor mice. **P < 0.01, ****P < 0.0001. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)