Fig. 5.

Influence of PERK inhibitor GSK2606414 on tumor cell proliferation on Mg, Mg–6Ag. (A) cLSM: Saos-eGFP (green), RF Fibroblasts (red, Ki-67 (white), cell nuclei (blue). Conditions: normoxia, 5 μM GSK2606414 for 72 h. Glass control without PERK inhibitor treatment. Scale bar 50 μm. (B) Quantification: relative numbers of Ki-67 positive cells (coculture) as m±sd from two samples with three randomly chosen positions for each sample. Significance differences between relative Ki-67 positive cells on different materials and treatment were obtained via a two-way ANOVA with Tukey's multiple comparison test (n = 6); **** = p < 0.0001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)