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. 2022 Mar 16;13:839502. doi: 10.3389/fimmu.2022.839502

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Copyright © 2022 Du, Ma, Zheng, Huang, Yang, Song, Dong, Shi and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATF3 regulates GSN and cytoskeleton remodeling for macrophage motility and recruitment. (A) Representative images of the actin cytoskeleton stained with phalloidin in WT and ATF3 KO BMDM cells and cells infected with S. aureus (MOI = 1). The white arrow indicates F-actin. (B) The intensity of F-actin is quantified on the right (*P < 0.05). (C, D) The GSN expression was analysis by the qPCR analysis and immunoblotting assay between WT and ATF3 KO BMDM cells with or without S. aureus infection. (E) The effect of S. aureus infection on WT and ATF3 KO BMDM cells migration was evaluated by trans-well assay in 24h. (F) Quantitative analysis of the cell migration ratio in (E). ns, P > 0.05, *P < 0.05, **P < 0.01.