Fig. 5.

Effect of wireless electrical stimulation on tumor chemotherapy in vivo. (a) Schematic diagram of the treatment plan of combined chemotherapy drugs. (b) Photographs of the tumors taken from the A375 tumor-bearing nude mice at the end of the antitumor studies. c, Tumor volume. Data are mean ± s.d. of biological replicates (n = 6). (d) Tumor weight. Data are mean ± s.d. of biological replicates (n = 6). (e) Body weight. Data are mean ± s.d. of biological replicates (n = 6). (f) H&E, Ki67 and TUNEL staining of tumor sections. *p < 0.05, **p < 0.01 or ***p < 0.001. Tumor vascular normalization induced by wireless electrical stimulation could potentiate doxorubicin efficacy.