Fig. 2.

Comparison of histological osteonecrosis and TRAP-positive osteoclasts at MRONJ-like lesions (A) Representative H&E staining and TRAP staining images of extracted tooth socket 8 weeks after removal in three groups. Imp, implant. M, molar. Nec, necrotic bone. Yellow arrow points the empty lacunae. Black arrow points the TRAP-positive stained osteoclast. Scale bar in H&E stain: 1 ​mm. Scale bar in TRAP stain: 100 ​μm (B) Histomorphometric assessments of H&E staining on the degree of alveolar bone necrosis, and TRAP staining on the number of TRAP-positive cells among groups. Column and bar indicate mean and SD, respectively. Veh ​+ ​Ti group n ​= ​5, BP ​+ ​Ti group n ​= ​9, and BP ​+ ​Mg group n ​= ​10, by One-way ANOVA with Bonferroni post hoc test. ∗, p ​< ​0.05. ∗∗, p ​< ​0.01. ∗∗∗, p ​< ​0.001.