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. 2022 Mar 28;33:153–161. doi: 10.1016/j.jot.2022.03.004

Fig. 4.

Fig. 4

Mg enhanced angiogenesis and coupled osteogenesis in MRONJ, which could be inhibited by blocking VEGF receptor-2 and CGRP receptor simultaneously, as indicated by micro-CT based angiography and bone histomorphometry analysis (A) Representative 3D reconstructed images of micro-CT based angiography showing the differences of vessel volume compared among the BP ​+ ​Ti, BP ​+ ​Mg, and BP ​+ ​Mg ​+ ​inhibitor/antagonist groups at 8 weeks after surgery. Scale bar: 5 ​mm (B) Quantitative analysis of angiography in different groups at 8 weeks after surgery (C) Representative 3D reconstructed images showing the differences of newly formed bone in the defect compared among groups at 8 weeks after surgery. Scale bar: 1 ​mm (D) Quantitative analysis of newly formed bone in different groups at 8 weeks after surgery. SU5416, VEGF receptor-2 inhibitor; BIBN, CGRP receptor antagonist. Column and bar indicate mean and SD, respectively. n ​= ​4–5 for each group, by One-way ANOVA with Bonferroni post hoc test. ∗, p ​< ​0.05; ∗∗, p ​< ​0.01; ∗∗∗, p ​< ​0.001.