Table III.

Rates of deep infection rates at 12 months.

Deep infection complication	NPWT group, n (%)	Standard wound dressing group, n (%)	Odds ratio (95% CI)	p-value*
Analysis 1: Participants with Gustilo-Anderson II or IIIA or IIIB open fractures (n = 1,322 patients; 116 events)	n = 266 patients 50 (18.8)	n = 1,056 patients 66 (6.3)	4.52 (1.84 to 11.12)	0.001
Analysis 2: Participants with Gustilo-Anderson II or IIIA open fractures (IIIB fractures excluded) (n = 1,149 patients; 91 events)	n = 172 patients 31 (18.0)	n = 977 patients 60 (6.1)	4.16 (0.86 to 20.25)	< 0.001
Analysis 3: Exclusion of participants with more than four irrigation and debridement procedures done during reoperation (n = 1,308 patients; 102 events)	n = 253 patients 42 (16.6)	n = 1,055 patients 60 (5.7)	3.81 (1.53 to 9.47)	0.004

^*Mixed effects logistic regression analysis.

CI, confidence interval; NWPT, negative pressure wound therapy.