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. 2022 Mar 16;13:840935. doi: 10.3389/fimmu.2022.840935

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Copyright © 2022 de Krijger, Hageman, Li Yim, Verhoeff, Garcia Vallejo, van Hamersveld, Levin, Hakvoort, Wildenberg, Henneman, Ponsioen and de Jonge

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gradient boosting analysis distinguishes PSC-UC from UC. (A) Heatmap of 18 differentially methylated positions contributing to the predictive model distinguishing PSC-UC from UC. (B) Radar plot depicting the 15 most predictive CpG loci that are capable of distinguishing patients with PSC-UC from UC. The axes represent the mean scaled changes for the top 15 most discriminative CpG sites.