Table 2.
Differentially methylated positions (DMPs) when comparing PSC-UC with UC.
| Location | Associated gene | Chromosome | Difference in methylation in PSC-UC vs UC | p-value | Adj. p-value | Name |
|---|---|---|---|---|---|---|
| cg02169981 | WNT11 | Chr 11 | Hypomethylation | 2.20E-06 | 0.770179 | Wnt Family Member 11 |
| cg26193427 | INPP5A | Chr 10 | Hypermethylation | 5.44E-06 | 0.770179 | Inositol Polyphosphate-5-Phosphatase A |
| cg07953344 | NRP2 | Chr 2 | Hypomethylation | 5.59E-06 | 0.770179 | Neuropilin 2 |
| cg17421991 | MNX1 | Chr 7 | Hypermethylation | 5.80E-06 | 0.770179 | Motor Neuron And Pancreas Homeobox 1 |
| cg08012199 | ARHGAP20* | Chr 11 | Hypermethylation | 6.23E-06 | 0.770179 | Rho GTPase Activating Protein 20 |
| cg27019059 | RYK* | Chr 3 | Hypomethylation | 8.73E-06 | 0.770179 | Receptor Like Tyrosine Kinase |
| cg13200031 | FAM163A | Chr 1 | Hypermethylation | 9.66E-06 | 0.770179 | Family With Sequence Similarity 163 Member A |
| cg09990876 | Chr 1 | Hypermethylation | 1.04E-05 | 0.770179 | ||
| cg00753630 | ATP6VOE2-AS1 | Chr 7 | Hypermethylation | 1.18E-05 | 0.770179 | Vacuolar Proton Pump Subunit E 2 |
| cg18617091 | TIMPRSS6 | Chr 22 | Hypomethylation | 1.36E-05 | 0.770179 | Transmembrane Serine Protease 6 |
The 10 most differentially methylated positions. *Neighbour gene. P-values were calculated through linear regression using limma and adjusted for multiple testing using the Benjamini–Hochberg method.