Table 3.
Location | Associated gene | Chromosome | Difference in methylation in PSC-UC vs UC | Feature Importance | Name |
---|---|---|---|---|---|
cg01201512 | NINJ2 | Chr 12 | Hypermethylation | 1.442312 | Nerve Injury-Induced Protein 2, Ninjurin-2 |
cg12219587 | Hypermethylation | 1.295918 | |||
cg19577958 | SERPINB9 | Chr 6 | Hypermethylation | 1.265306 | Serpin Family B Member 9, Serpin B9, Granzyme B inhibitor |
cg00980980 | Hypomethylation | 0.858523 | |||
cg26371957 | NINJ2 | Chr 12 | Hypermethylation | 0.639473 | Nerve Injury-Induced Protein 2, Ninjurin-2 |
cg27224751 | DNAJC17 | Chr 15 | Hypermethylation | 0.632653 | DnaJ Heat Shock Protein Family (Hsp40) Member C17 |
cg19079513 | Hypermethylation | 0.612245 | |||
cg14911689 | NINJ2 | Chr 12 | Hypermethylation | 0.583521 | Nerve Injury-Induced Protein 2, Ninjurin-2 |
cg13556794 | OR51A7 | Chr 11 | Hypermethylation | 0.520408 | Olfactory Receptor Family 51 Subfamily A Member 7, Odorant receptor |
cg00257789 | TRAPPC12/TTC15 | Chr 2 | Hypomethylation | 0.448323 | Trafficking Protein Particle Complex 12 |
cg26846609 | THUMPD1 | Chr 16 | Hypomethylation | 0.397421 | THUMP domain-containing protein 1 |
cg17018422 | TRAPPC12/TTC15 | Chr 2 | Hypomethylation | 0.355172 | Trafficking Protein Particle Complex 12 |
cg05696779 | CYP4F22 | Chr 19 | Hypomethylation | 0.306122 | Cytochrome P450 family 4 subfamily F member 22 |
cg12313868 | Hypermethylation | 0.244898 | |||
cg00853216 | SOX6 | Chr 11 | Hypermethylation | 0.204082 | Transcription factor SOX-6 |
cg26654770 | NINJ2 | Chr 12 | Hypermethylation | 0.196723 | Nerve Injury-Induced Protein 2, Ninjurin-2 |
cg06377160 | SNX19 | Chr 11 | Hypomethylated | 0.173469 | Sorting nexin-19 |
cg16402757 | CUL2 | Chr 10 | Hypermethylated | 0.134404 | Cullin-2 |
The 18 CpG loci returned by gradient boosting that were capable of distinguishing PSC-UC from UC.