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. 2022 Mar 16;13:840935. doi: 10.3389/fimmu.2022.840935

Table 3.

Predictor CpG loci capable of distinguishing PSC-UC from UC.

Location Associated gene Chromosome Difference in methylation in PSC-UC vs UC Feature Importance Name
cg01201512 NINJ2 Chr 12 Hypermethylation 1.442312 Nerve Injury-Induced Protein 2, Ninjurin-2
cg12219587 Hypermethylation 1.295918
cg19577958 SERPINB9 Chr 6 Hypermethylation 1.265306 Serpin Family B Member 9, Serpin B9, Granzyme B inhibitor
cg00980980 Hypomethylation 0.858523
cg26371957 NINJ2 Chr 12 Hypermethylation 0.639473 Nerve Injury-Induced Protein 2, Ninjurin-2
cg27224751 DNAJC17 Chr 15 Hypermethylation 0.632653 DnaJ Heat Shock Protein Family (Hsp40) Member C17
cg19079513 Hypermethylation 0.612245
cg14911689 NINJ2 Chr 12 Hypermethylation 0.583521 Nerve Injury-Induced Protein 2, Ninjurin-2
cg13556794 OR51A7 Chr 11 Hypermethylation 0.520408 Olfactory Receptor Family 51 Subfamily A Member 7, Odorant receptor
cg00257789 TRAPPC12/TTC15 Chr 2 Hypomethylation 0.448323 Trafficking Protein Particle Complex 12
cg26846609 THUMPD1 Chr 16 Hypomethylation 0.397421 THUMP domain-containing protein 1
cg17018422 TRAPPC12/TTC15 Chr 2 Hypomethylation 0.355172 Trafficking Protein Particle Complex 12
cg05696779 CYP4F22 Chr 19 Hypomethylation 0.306122 Cytochrome P450 family 4 subfamily F member 22
cg12313868 Hypermethylation 0.244898
cg00853216 SOX6 Chr 11 Hypermethylation 0.204082 Transcription factor SOX-6
cg26654770 NINJ2 Chr 12 Hypermethylation 0.196723 Nerve Injury-Induced Protein 2, Ninjurin-2
cg06377160 SNX19 Chr 11 Hypomethylated 0.173469 Sorting nexin-19
cg16402757 CUL2 Chr 10 Hypermethylated 0.134404 Cullin-2

The 18 CpG loci returned by gradient boosting that were capable of distinguishing PSC-UC from UC.