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. 2022 Mar 14;18:321–336. doi: 10.1016/j.bioactmat.2022.02.035

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — 3D Spheroids treated with G^M-Dye constructs. Confocal Fluorescence Microscopy (CFM) images of 3D tumor spheroids treated with G^X, G^L or G^CC nanoparticles tagged with Rhodamine-B (RhB), or Cyanine-5 (Cy5) dye, at various penetration depths (10–50 μm). (a and b respectively) NCI-ADR-RES and A549 spheroids treated with G^M-RhB constructs. (b and c respectively) NCI-ADR-RES and A549 spheroids treated with G^M-Cy5 constructs. The images are representative. The difference in linear z compensation applied during imaging prevented comparisons of raw-intensity between sections/spheroids. (M = X, L or CC).