Table 3.
Incidence rates of virus-specific LRTIs per 100 child-years and IRRs for severe LRTI compared to non-severe LRTI in Biliran, Philippines, from March 2014 to June 2016
| Detected virus | LRTI classification | 0–5 months | 6–11 months | 12–23 months | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | IR | [95%CI] | IRR | [95%CI] | n | IR | [95%CI] | IRR | [95%CI] | n | IR | [95%CI] | IRR | [95%CI] | ||
| AdV | Non-severe | 0 | 0.0 | [0.0–2.1] | 1 | 2 | 1.4 | [0.2–5.0] | 1 | 1 | 0.7 | [0.0–3.7] | 1 | |||
| Severe | 0 | 0.0 | [0.0–2.1] | 0.00 | [0.00–0.00] | 0 | 0.0 | [0.0–2.5] | 0.00 | [0.00–5.32] | 0 | 0.0 | [0.0–2.4] | 0.00 | [0.00–39.00] | |
| Total | 0 | 0.0 | [0.0–2.1] | – | – | 2 | 1.4 | [0.2–5.0] | – | – | 1 | 0.7 | [0.0–3.7] | – | – | |
| RV | Non-severe | 24 | 13.7 | [8.8–20.4] | 1 | 13 | 8.9 | [4.8–15.3] | 1 | 22 | 14.5 | [9.1–21.9] | 1 | |||
| Severe | 15 | 8.6 | [4.8–14.1] | 0.63 | [0.30–1.24] | 7 | 4.8 | [1.9–9.9] | 0.54 | [0.18–1.45] | 4 | 2.6 | [0.7–6.7] | 0.18 | [0.05–0.54] | |
| Total | 39 | 22.3 | [15.8–30.4] | – | – | 21 | 14.4 | [8.9–22.0] | - | - | 27 | 17.7 | [11.7–25.8] | – | – | |
| EV | Non-severe | 1 | 0.6 | [0.0–3.2] | 1 | 2 | 1.4 | [0.2–5.0] | 1 | 3 | 2.0 | [0.4–5.8] | 1 | |||
| Severe | 2 | 1.1 | [0.1–4.1] | 2.00 | [0.10–117.99] | 1 | 0.7 | [0.0–0.0] | 0.50 | [0.01–9.60] | 1 | 0.7 | [0.0–3.7] | 0.33 | [0.01–4.15] | |
| Total | 3 | 1.7 | [0.4–5.0] | – | – | 3 | 2.1 | [0.4–6.0] | - | - | 4 | 2.6 | [0.7–6.7] | – | – | |
| RSV | Non-severe | 15 | 8.6 | [4.8–14.1] | 1 | 3 | 2.1 | [0.4–6.0] | 1 | 12 | 7.9 | [4.1–13.8] | 1 | |||
| Severe | 11 | 6.3 | [3.1–11.2] | 0.73 | [0.30–1.71] | 7 | 4.8 | [1.9–9.9] | 2.33 | [0.53–13.98] | 5 | 3.3 | [1.1–7.7] | 0.42 | [0.11–1.27] | |
| Total | 27 | 15.4 | [10.2–22.4] | – | – | 11 | 7.6 | [3.8–13.5] | – | – | 18 | 11.8 | [7.0–18.7] | – | – | |
| MPV | Non-severe | 1 | 0.6 | [0.0–3.2] | 1 | 1 | 0.7 | [0.0–3.8] | 1 | 4 | 2.6 | [0.7–6.7] | 1 | |||
| Severe | 1 | 0.6 | [0.0–3.2] | 1.00 | [0.01–78.50] | 0 | 0.0 | [0.0–2.5] | 0.00 | [0.00–39.00] | 2 | 1.3 | [0.2–4.7] | 0.50 | [0.05–3.49] | |
| Total | 2 | 1.1 | [0.1–4.1] | – | – | 1 | 0.7 | [0.0–3.8] | – | – | 6 | 3.9 | [1.5–8.6] | – | – | |
| PIV | Non-severe | 4 | 2.3 | [0.6–5.8] | 1 | 7 | 4.8 | [1.9–9.9] | 1 | 11 | 7.2 | [3.6–12.9] | 1 | |||
| Severe | 2 | 1.1 | [0.1–4.1] | 0.50 | [0.05–3.49] | 4 | 2.7 | [0.7–7.0] | 0.57 | [0.12–2.25] | 0 | 0.0 | [0.0–2.4] | 0.00 | [0.00–0.40] | |
| Total | 6 | 3.4 | [1.37.5] | – | – | 11 | 7.6 | [3.8–13.5] | – | – | 11 | 7.2 | [3.6–12.9] | – | – | |
| IFV | Non-severe | 3 | 1.7 | [0.4–5.0] | 1 | 4 | 2.7 | [0.7–7.0] | 1 | 4 | 2.6 | [0.7–6.7] | 1 | |||
| Severe | 1 | 0.6 | [0.0–3.2] | 0.33 | [0.01–4.15] | 3 | 2.1 | [0.4–6.0] | 0.75 | [0.11–4.43] | 3 | 2.0 | [0.4–5.8] | 0.75 | [0.11–4.43] | |
| Total | 5 | 2.9 | [0.9–6.7] | – | – | 7 | 4.8 | [1.9–9.9] | – | – | 7 | 4.6 | [1.9–9.5] | – | – | |
| Co-detection | Non-severe | 7 | 4.0 | [1.6–8.2] | 1 | 3 | 2.1 | [0.4–6.0] | 1 | 1 | 0.7 | [0.0–3.7] | 1 | |||
| Severe | 2 | 1.1 | [0.1–4.1] | 0.29 | [0.03–1.50] | 1 | 0.7 | [0.0–3.8] | 0.33 | [0.01–4.15] | 1 | 0.7 | [0.0–3.7] | 1.00 | [0.01–78.50] | |
| Total | 9 | 5.1 | [2.4–9.8] | – | – | 4 | 2.7 | [0.8–7.0] | – | – | 3 | 2.0 | [0.4–5.8] | – | – | |
| Negative | Non-severe | 20 | 11.4 | [7.0–17.6] | 1 | 20 | 13.7 | [8.4–21.2] | 1 | 28 | 18.4 | [12.2–26.6] | 1 | |||
| Severe | 11 | 6.3 | [3.1–11.2] | 0.55 | [0.24–1.20] | 13 | 8.9 | [4.8–15.3] | 0.65 | [0.30–1.37] | 7 | 4.6 | [1.8–9.5] | 0.25 | [0.09–0.59] | |
| Total | 31 | 17.7 | [12.0–25.1] | – | – | 34 | 23.3 | [16.2–32.6] | – | – | 36 | 23.7 | [16.6–32.8] | – | – | |
| Total | Non-severe | 75 | 42.8 | [33.7–53.7] | 1 | 55 | 37.8 | [28.4–49.1] | 1 | 86 | 56.5 | [45.2–69.8] | 1 | |||
| Severe | 45 | 25.7 | [18.7–34.4] | 0.61 | [0.41–0.88] | 36 | 24.7 | [17.3–34.2] | 0.65 | [0.42–1.01] | 23 | 15.1 | [9.6–22.7] | 0.27 | [0.16–0.43] | |
| Total | 122 | 69.6 | [57.8–83.2] | – | – | 94 | 64.5 | [52.1–79.0] | – | – | 113 | 74.3 | [61.2–89.3] | – | – | |
Total LTRTI included non-severe LRTI, severe LRTI and undefined LRTI. Observed child-years were 175.2, 145.7, and 152.2 at age 0–5, 6–11, and 12–23 months, respectively. Episodes in which samples were not tested for virus detection were excluded (n = 21)
IR, incidence rate; IRR, incidence rate ratio; LRTI, lower respiratory tract infection; 95%CI, 95% confidence interval; AdV, Adenovirus; RV, Rhinovirus; EV, Enterovirus; RSV, Respiratory syncytial virus; MPV, Human metapneumovirus; PIV, Parainfluenza virus; IFV, Influenza virus