Table 2.
Cytokine serum levels in vitamin D sufficient or deficient mice treated either with vehicle or 1α,25(OH)2D3 followed by LPS. Interleukin (IL), Tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) expressed as pg/ml, - : below detection limit
| Serum | |||||
|---|---|---|---|---|---|
| Sufficient | Deficient | ||||
| Vehicle | 1α,25(OH)2D3 | Vehicle | 1α,25(OH)2D3 | ||
| IL-1β | – | – | – | – | |
| IL-6 | 115 (78.5–161) | 189 (149–433)# | 152 (77.5–367) | 125 (89–195) | |
| IL-10 | 25.3 (16.8–42.8) | 78.5 (43.3–157)# | 36.9 (22.4–816) | 25.2 (19.0–34.6) | |
| IL-13 | – | – | – | – | |
| IL-17A | 0.3 (0.2–0.4) | 0.5 (0.3–0.7) | 1.4 (0.06–10.3) | 0.2 (0.1–0.5) | |
| TNF-⍺ | 19.0 (12.4–27.0) | 21.8 (16.7–36.2) | 52.7 (23.7–143) | 17.3 (15.5–22.6) | |
| IFN-γ | 0.9 (0.5–1.2) | 1.5 (0.5–19.0) | 3.8 (0.5–20.8) | 3.8 (0.4–8.3) | |
#: p < 0.05 1α,25(OH)2D3 sufficient vs vehicle sufficient (Mann Whitney). Data are expressed as median ± IQR with n = 6/group