FIGURE 1.

Changes in CHRM1 mRNA expression levels are associated with changes in the expression levels of APC, CTNNB1, and SMAD4. We used univariate mixed models with participant ID as a random effect to model processed (low count filtered, quantile normalized, log2 transformed, and batch corrected) CHRM1 expression data as a function of key genes in colorectal cancer. CHRM1 expression levels was significantly associated with APC (A), CTNNB1 (encoding β-catenin) (B), and SMAD4 (C) expression levels, which showed differential clustering of values based on cancer status.