TABLE 2.

Log2 fold changes in CHRM1–4.

	Basic log2 fold change	Adjusted p-value	Limma-voom fold change	Adjusted p-value	edgeR fold change	Adjusted p-value
CHRM1	−0.2067	8.5897E-04	−0.3310	6.044E-05	−0.8446	6.791E-02
CHRM2	−0.7694	1.9037E-17	−1.1010	4.462E-21	−2.3380	3.025E-07
CHRM3	0.1477	4.2514E-02	0.1046	1.902E-01	0.09757	1.000
CHRM4	−0.4018	1.0158E-07	−0.6219	7.594E-11	−1.8890	1.426E-04

Log2fc was assessed for CHRM1–4 levels in adenocarcinoma vs. solid normal colorectal tissue samples using basic fold changes, limma-voom, and edgeR normalization, respectively, employing the processing scheme illustrated in Supplementary Figure 1B.