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. 2022 Mar 26;15:15. doi: 10.1186/s12245-022-00408-6

Table 1.

Clinical presentation of histamine- and bradykinin-induced angioedema [14]

Types of angioedema Histamine induced Bradykinin induced
Causes

-Allergy (anaphylaxis)

-Non-allergic

-Spontaneous (idiopathic)

-Hereditary (HAE)

-Acquired

-Drug induced (e.g. ACEi)

Presence of urticaria Possible No
Onset Rapid (min) Slower (hours)
Duration Hours Days
Abdominal pain Could happen Frequent (by history)
Asthmatic response Frequent No
Hypotension Common No
Response to standard treatment (epinephrine, antihistamines, corticosteroids) Effective No or minimal response