Table 3.
nsSNPs and fsIndels in genes conferring resistance to LEV
| Gene | Sequence change | No. among LEV-R (n = 39) | No. among LEV-S (n = 73) | P | |
|---|---|---|---|---|---|
| Nucleotide position | Amino acid position | ||||
| gyrA | SNP | ||||
| C261A | N87T | 8 (20.51%) | 0 (0.00%) | 0.0001 | |
| C261G | N87I | 9 (23.08%) | 0 (0.00%) | < 0.0001 | |
| G271A | D91G | 12 (30.77%) | 0 (0.00%) | < 0.0001 | |
| G271T | D91Y | 5 (1.67%) | 0 (0.00%) | 0.0043 | |
| Indel | |||||
| 2455_2456insAT (AC to AATC) | T819fs | 32 (82.05%) | 57 (78.08%) | 0.6203 | |
| 2460_2463del (CTTCG to C) | S820fs | 34 (87.18%) | 62 (84.93%) | 0.7460 | |
| 2472delT (AT to A) | N824fs | 38 (97.44%) | 66 (90.41%) | 0.2577 | |
| No change | No change | 1 (2.56%) | 7 (9.59%) | 0.2577 | |
| gyrB | SNP | ||||
| C1801T | L601F | 37 (94.87%) | 73 (100.00%) | 0.3423 | |
| No change | No change | 2 (5.13%) | 0 (0.00%) | 0.1192 | |