Fig. 2.

Receiver operating characteristic curves from different combinations of markers related to conversion to AD dementia. Receiver operating characteristic curves from logistic regression models discriminating MCI patients who progressed to AD dementia within 3 years (n = 23) vs. those who did not (n = 77) in the subsample with plasma p-tau217 and all other AD markers of interest (global cognition from mPACC, hippocampal volume and APOE4 status). All details of the different models are reported in Table 3. APOE, apolipoprotein E genotype (carrying at least one ε4 allele); AUC, area under the curve; hipp, hippocampal volume (adjusted for total intracranial volume); mPACC, modified Preclinical Alzheimer’s Cognitive Composite; p-tau217, phosphorylated tau 217