Table 3.
Association of plasma p-tau217, cognition, hippocampal volume, and APOE4 genotype with conversion to AD dementia
| n = 100 | Model | Odds ratio (p-value) | |||||
|---|---|---|---|---|---|---|---|
| AICc | AUC [95% CI] | Model comparisons | p-tau217 | mPACC | Hipp. volume | APOE4 | |
| Model 1 (Full model) | 82.0 | 0.889 [0.824, 0.954] |
1 vs. 2 or 3: p = 0.10 1 vs. 4: p = 0.07 1 vs. 5: p = 0.01 1 vs. ref: p = 0.001 |
2.25 (0.021) | 0.43 (0.008) | 0.60 (0.12) | 2.81 (0.10) |
| Model 2 | 82.3 | 0.868 [0.796, 0.941] | 2 vs. ref: p = 0.001 | 2.66(0.005) | 0.38 (0.002) | 2.76 (0.099) | |
| Model 3 | 82.5 | 0.875 [0.798, 0.953] | 3 vs. ref: p = 0.001 | 2.71 (0.004) | 0.43 (0.009) | 0.60 (0.12) | |
| Model 4 | 82.9 | 0.866 [0.787, 0.945] | 4 vs. ref: p = 0.001 | 3.22 (0.0007) | 0.38 (0.002) | ||
| Model 5 | 86.4 | 0.848 [0.768, 0.929] | 5 vs. ref: p = 0.007 | 0.42 (0.006) | 0.48 (0.017) | 4.33 (0.011) | |
| Reference model | 91.9 | 0.831 [0.743, 0.920] | – | 3.14 (0.0001) | |||
Results from logistic regression models discriminating MCI patients who progressed to AD dementia within 3 years (n = 23) vs. those who did not (n = 77) in the subsample with plasma p-tau217 and all other AD markers of interest (global cognition from mPACC, hippocampal volume and APOE4 status). Models are ordered based on AICc (lower values representing better model fit) and odds ratio (p-value) of each variable included in the corresponding models are reported. Odds ratio values represent the “increased risk” of converting to AD dementia for each increase in standard deviation of the marker value. Note that a difference in AICc greater than 2 between models would imply a better fit for the model with the lowest AICc. Model including plasma p-tau217 only was included as the reference model. Comparisons between models were performed using ANOVA and p-values are reported
Abbreviations: AICc corrected Akaike information criteria, APOE4 apolipoprotein E genotype (carrying at least one ε4 allele), AUC area under the curve, Hipp. volume hippocampal volume (adjusted for total intracranial volume), mPACC modified Preclinical Alzheimer’s Cognitive Composite, p-tau217 phosphorylated tau 217, ref Reference model (p-tau217 only)