Table 4.
Association of plasma p-tau217, cognition, and hippocampal volume with conversion to AD dementia
| n = 110 | Model | Odds ratio (p-value) | ||||
|---|---|---|---|---|---|---|
| AICc | AUC [95% CI] | Model comparisons | p-tau217 | mPACC | Hipp. volume | |
| Full model (model 1) | 91.1 | 0.878 [0.806, 0.951] |
1 vs. 2: p = 0.14 1 vs. 3: p = 0.01 1 vs. ref: p = 0.003 |
3.16 (0.0002) | 0.47 (0.013) | 0.65 (0.15) |
| Model 2 | 91.1 | 0.862 [0.784, 0.940] | 2 vs. ref: p = 0.002 | 3.54 (< 0.0001) | 0.43 (0.004) | |
| Model 3 | 95.7 | 0.866 [0.799, 0.933] | 3 vs. ref: p = 0.024 | 2.88 (< 0.0001) | 0.52 (0.030) | |
| Reference model | 98.7 | 0.842 [0.763, 0.922] | – | 3.13 (< 0.0001) | ||
Results from logistic regression models discriminating MCI patients who progressed to AD dementia within three years (n = 26) vs. those who did not (n = 84) in the full sample with plasma p-tau217, global cognition from mPACC, and hippocampal volume. Models are ordered based on AICc (lower values representing better model fit) and odds ratio (p-value) of each variable included in the corresponding models are reported. Odds ratio values represent the “increased risk” of converting to AD dementia for each increase in standard deviation of the marker value. Note that a difference in AICc of 2 between models would imply a better fit for the model with the lowest AICc. Model including plasma p-tau217 only was included as the reference model. Comparisons between models were performed using ANOVA and p-values are reported
Abbreviations: AICc corrected Akaike information criteria, AUC area under the curve, Hipp. volume hippocampal volume (adjusted for total intracranial volume), mPACC modified Preclinical Alzheimer’s Cognitive Composite, p-tau217 phosphorylated tau 217, ref Reference model (p-tau217 only)