Table 2.
The frequencies of included variables in both the cohort with impaired and not affected renal function
| Variables | eGFR ≤ 90% of preoperative level N = 81 |
Missing values | eGFR > 90% of preoperative level n = 646 |
Missing values | P value |
|---|---|---|---|---|---|
| Pre-operative variables | |||||
| Female gender | 31 (38.3%) | 0 (0%) | 254 (39.3%) | 0 (0%) | 0.856a |
| Male gender | 50 (61.7%) | 0 (0%) | 392 (60.7%) | 0 (0%) | |
| UICC I | 6 (9.0%) | 14 (17.3%) | 51 (7.9%) | 92 (14.2%) | 0.901b |
| UICC IIa | 14 (17.3%) | 90 (13.9%) | |||
| UICC IIb | 0 (0%) | 8 (1.2%) | |||
| UICC IIc | 0 (0%) | 0 (0%) | |||
| UICC IIIa | 2 (2.5%) | 17 (2.6%) | |||
| UICC IIIb | 7 (8.6%) | 78 (12.1%) | |||
| UICC IIIc | 3 (3.7%) | 24 (3.7%) | |||
| UICC IV | 35 (82.7%) | 554 (85.8%) | |||
| Chemotherapy of primary tumor | 53 (65.4%) | 2 (2.5%) | 427 (66.1%) | 9 (1.4%) | 0.992a |
| Time to metastases (years) | 1.27 (0–17) | 4 (4.9%) | 1.34 (0–14) | 12 (1.9%) | 0.785c |
| Synchronous metastases (%) | 35 (43.2%) | 2 (2.5%) | 250 (38.7%) | 7 (1.1%) | 0.375a |
| Number of CRLM | 2.5 (1–10) | 1 (1.2%) | 2.4 (1–11) | 11 (1.7%) | 0.590c |
| Age at liver resection (years) | 65.3 (26–87) | 0% | 61.7 (24–90) | 0% | 0.005c |
| Platelets Tsd/μl (NR 160–370) | 250 (96–794) | 1 (1.2%) | 244 (15–977) | 4 (0.6%) | 0.548c |
| Hemoglobin g/dl (NR 11.8–15.8) | 13.4 (9.1–16.8) | 0% | 13.4 (8.2–18.3) | 4 (0.6%) | 0.857c |
| Quick % (NR 70–130) | 99.3 (63–137) | 1 (1.2%) | 99.1 (10–145) | 8 (1.2%) | 0.904c |
| Preoperative eGFR (NR 90–130 ml/min) | 84.9 (40.3–150.8) | 0 (0%) | 89.4 (4.9–130.2) | 0 (0%) | 0.022c |
| Preoperative eGFR < 90 ml/min | 56 (69.1%) | 307 (47.5%) | < 0.001a | ||
| Operative details and characteristics of metastases | |||||
| Minor liver resection | 45 (55.6%) | 0 (0%) | 372 (57.6%) | 0 (0%) | 0.728a |
| Major liver resection | 36 (44.4%) | 274 (42.4%) | |||
| Operative duration in min | 174 (40–385) | 0 (0%) | 163 (40–606) | 4 (0.6%) | 0.114c |
| Use of Pringle’s maneuver (in N cases) | 25 (30.9%) | 3 (3.7%) | 201 (31.1%) | 27 (4.2%) | 0.963a |
| Pringle’s procedure in min if used | 24.4 (7–72) | 23.3 (4–63) | 0.465c | ||
| Intraoperative transfusion of PRBC | 1.7 (0–13) | 0 (0%) | 1.2 (0–42) | 0 (0%) | 0.125c |
| Postoperative transfusion of PRBC | 1.2 (0–17) | 0.8 (0–49) | 0.266c | ||
| Overall transfusion of PRBC | 2.9 (0–21) | 2.0 (0–58) | 0.089c | ||
| Size of largest metastasis in mm | 44.7 (2–200) | 3 (3.7%) | 50.3 (4–220) | 38 (5.9%) | 0.175c |
| Weight of liver specimen in g | 410 (2.2–2070) | 3 (3.7%) | 445 (2.8–4860) | 34 (5.3%) | 0.530c |
| Distance to resection margin in mm | 4.4 (0–35) | 5 (6.2%) | 5.9 (0–70) | 35 (5.4%) | 0.139c |
| R-status R0 | 70 (86.4%) | 1 (1.2%) | 588 (91.0%) | 8 (1.3%) | 0.083b |
| R-status R1 | 9 (11.1%) | 48 (7.4%) | |||
| R-status R2 | 1 (1.2%) | 2 (0.3%) | |||
| eGFR at hospital dismission (Reference 90–130 ml/min) | 64.5 (15.5–124-7) | 0 (0%) | 93.9 (6.5–138-7) | 0 (0%) | < 0.001c |
| Dindo-Clavien classification of surgical complications grade 1 | 2 (2.5%) | 0 (0%) | 17 (2.6%) | 0 (0%) | 0.005b |
| Dindo-Clavien classification of surgical complications grade 2 | 17 (21.0%) | 97 (15.0%) | |||
| Dindo-Clavien classification of surgical complications grade 3 | 11 (13.6%) | 67 (10.4%) | |||
| Dindo-Clavien classification of surgical complications grade 4 | 6 (7.4%) | 14 (2.2%) | |||
| Complications graded Dindo-Clavien > 3 | 17 (21%) | 81 (12.6%) | 0.065a | ||
Data presented in N (%) or mean (ranges)
NR Normal range
aChi-square test
bKruskal-Wallis test
ct test