Table 4.

Results of the Cox regression analyses and multivariable Cox regression analyses on variables with impact on overall survival. In-house mortality cases were excluded

Variables	Univariable Cox regression		Multivariable Cox regression
	p value	HR (95%-CI)	p value	HR (95%-CI)
Preoperative variables
Chemotherapy on primary tumor (Ref. yes)	< 0.001	0.722 (0.604–0.863)	0.002	0.732 (0.603–0.888)
Development of CRLM (Ref. metachronous)	0.101	1.151 (0.973–1.361)	0.835	Not applicable
Age at liver resection > 70 years	0.009	1.290 (1.066–1.562)	0.005	1.357 (1.095–1.683)
Number of CRLM	< 0.001	1.115 (1.076–1.156)	0.001	1.071 (1.028–1.115)
Size of CRLM > 50 mm	< 0.001	1.416 (1.200–1.671)	0.018	1.256 (1.040–1.517)
Preoperative hemoglobin	0.017	0.939 (0.891–0.989)	0.683	Not applicable
Preoperative platelets	0.148	1.001 (1.000–1.002)	0.339
Preoperative quick	0.127	0.996 (0.990–1.001)	0.826
Preoperative eGFR < 90 ml/min (Ref. normal values)	0.036	1.196 (1.012–1.413)	0.113
Intra- and postoperative variables
Extent of liver resection (Ref. minor)	0.038	1.190 (1.009–1.404)	0.830
Operative duration > 120 min (Ref. no)	< 0.001	1.460 (1.192–1.788)	0.006	1.385 (1.096–1.749)
Use of Pringle’s maneuver (Ref. not used)	0.380	1.038 (0.907–1.293)	0.643	Not applicable
Weight of liver specimen > 450 g	0.062	1.170 (0.992–1.380)	0.295
Distance to resection margin in mm	0.005	0.984 (0.973–0.995)	0.041	0.988 (0.977–1.000)
R1-status (Ref. R0)	0.466	1.129 (0.815–1.564)	0.425	Not applicable
R2-status (Ref. R0)	0.261	1.658 (0.687–4.002)	0.440
Overall transfusion of > 2 units PRBC (Ref. no)	< 0.001	1.468 (1.243–1.734)	0.039	1.223 (1.010–1.482)
Postoperative complications graded Dindo-Clavien > 3 (Ref. no)	0.063	1.259 (0.988–1.605)	0.285	Not applicable
eGFR at dismission < 90% of preoperative eGFR (Ref. < 90%)	0.494	1.096 (0.843–1.423)	0.915
Stay on intensive care unit (days)	< 0.001	1.029 (1.016–1.042)	0.122
Overall hospital stay > 14 days (Ref.no)	< 0.001	1.382 (1.162–1.643)	0.190

HR Hazard ratio