Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 30;41:116. doi: 10.1186/s13046-022-02306-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — SCAP degradation induced by lycorine improves sorafenib resistance in HCC in vitro. PLC-SR cells (control) were treated with the SCAP inhibitor lycorine at a certain concentration gradient. A, B Immunoblot analysis of SCAP protein expression at different concentrations (n = 3). PLC-SR cells (control) were treated with lycorine (Ly) alone, sorafenib (Sora) alone or a combination of lycorine and sorafenib (Ly + Sora). C The viability of sorafenib-treated cells in each group. D Clone assays of 4 groups (n = 3). Scratch-wound cell migration (E), (G) and invasion (F), (H) assays for each group (n = 3). Flow cytometry analysis of the cell cycle (I), (K) and apoptosis (J), (L) of each group (n = 3). Bar = 100 μm. Data are the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. P values were determined by one-way ANOVA in (B), (C), (D), (G), (H) and (L) and repeated-measures ANOVA in (K)