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. 2022 Mar 30;41:116. doi: 10.1186/s13046-022-02306-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — SCAP degradation induced by lycorine improves sorafenib resistance in HCC in vivo. A Photographs of subcutaneous tumours after excision (n = 5). B, C Graphs (mean ± SD) showing tumour growth and tumour weight. D PCNA and SCAP staining in tumour tissues (n = 5). E Oil Red O staining in tumour tissues and liver tissues. Bar = 50 μm. The levels of TC and TGs in tumour tissues (n = 5). F Ultrastructural analysis of tumour tissues from each group. The red arrowhead represents autophagic vacuoles (n = 5). Bar = 50 μm. G Representative images of immunofluorescence staining of p-AMPK and P62 proteins in each group (n = 5). Bar = 100 μm. H Immunoblot analysis of SCAP, p-AMPK, t-AMPK, LC3 and P62 protein expression in each group (n = 5). Data are the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. P values were determined by one-way ANOVA in (C), (D), (E) and (F) and repeated-measures ANOVA in (B) and (H)