TABLE 3.

Degree of reproducibility of three different methods of reading, measured by ICC, among three serial MICs of four antifungals against 30 strains of filamentous fungi with three end point criteria and two times of reading

Reading type	Breakpoint (% growth inhibition)	Time of incubation (h)	ICC (95% CI)a with:
			Keto	Itra	5-FC	Ampho B
Visual	50	48	0.951 (0.912–0.974)	0.976 (0.957–0.988)	0.974 (0.953–0.986)
		72	0.970 (0.945–0.984)	0.984 (0.970–0.992)	0.965 (0.937–0.982)
	75	48	0.960 (0.929–0.979)	0.975 (0.956–0.987)	0.986 (0.973–0.993)
		72	0.960 (0.929–0.979)	0.974 (0.957–0.988)	0.975 (0.955–0.987)
	100	48				0.825 (0.709–0.905)
		72				0.916 (0.853–0.956)
Visual after agitation	50	48	0.961 (0.931–0.980)	0.976 (0.957–0.988)	0.982 (0.968–0.991)
		72	0.966 (0.939–0.983)	0.981 (0.966–0.990)	0.970 (0.947–0.985)
	75	48	0.955 (0.920–0.977)	0.976 (0.957–0.988)	0.984 (0.972–0.992)
		72	0.964 (0.936–0.981)	0.971 (0.948–0.985)	0.974 (0.953–0.987)
	100	48				0.811 (0.688–0.897)
		72				0.915 (0.850–0.956)
Spectrophotometric	50	48	0.860 (0.763–0.925)	0.948 (0.908–0.973)	0.970 (0.945–0.984)
		72	0.918 (0.857–0.957)	0.957 (0.924–0.978)	0.967 (0.941–0.983)
	75	48	0.850 (0.747–0.919)	0.894 (0.818–0.944)	0.971 (0.948–0.985)
		72	0.936 (0.888–0.967)	0.982 (0.967–0.991)	0.992 (0.986–0.996)
	100	48				0.808 (0.683–0.895)
		72				0.896 (0.819–0.946)

^aAntifungal agents are as defined in Table 1.