Extended Data Table 2 |.

The genomic locations of candidate LMI070-induced exons and the frequency of events from RNA-seq datasets—continued

		GRCh37 (hg19)
		Canonical Junction Metrics			LMI070 Junction1 Metrics					LMI070 Junction2 Metrics
	Gene ID	CJ exon-exon juction	CJ Intropolis Datasets	CJ_Total Counts	J1 Position	J1 Num Datasets	J1 % Data Sets	J1 Total Counts	J1 % Total counts	J2 Positon	J2 Num Datasets	J2 % Data Sets	J2 Total Counts	J2 % Total counts
Exclusive	SF3B3	chr16:70560630–70562775	12873	825337	chr16:70560630–70561278	10	0.08	13	0.002	chr16:70561333–70562775	1	0.01	1	0.0001
	BENC1	chr17:40962947–40963672	13635	910210	chr17:40962947–40963309	301	2.21	552	0.061	chr17:40963349–40963672	182	1.33	303	0.0333
	GXYLT1	chr12:42481750–42491243	7430	43383	chr12:42481750–42488952	8	0.11	9	0.021	chr12:42489017–42491243	79	1.06	97	0.2236
	SKP1	chr5:133509714–133512545	13277	2756168	chr5:133509714–133510974	15	0.11	16	0.001	chr5:133511077–133512545	6	0.05	6	0.0002
	SKP1	chr5:133509714–133512545	13277	2756168	chr5:133509714–133510974	15	0.11	16	0.001	chr5:133511115–133512545	13	0.10	18	0.0007
	C12orf4	chr12:4645386–4647574	9856	102163	chr12:4645386–4646545	354	3.59	563	0.551	chr12:4646681–4647574	579	5.87	1102	1.0787
	SSBP1	chr7:141438991–141441968	14501	2473164	chr7:141438991–141441109	38	0.26	71	0.003	chr7:141441260–141441968	41	0.28	60	0.0024
	RARS	chr5:167945068–167946085	13602	826669	chr5:167945068–167945373	20	0.15	21	0.003	chr5:167945529–167946085	7	0.05	7	0.0008
	RARS	chr5:167945068–167946085	13602	826669	chr5:167945068–167945473	2	0.01	2	0.000	chr5:167945529–167946085	7	0.05	7	0.0008
	PDXDC2P	chr16:70064970–70065802	9586	117767	chr16:70064970–70065088	284	2.96	587	0.498	chr16:70065152–70065802	1097	11.44	3160	2.6833
	STRADB	chr2:202334776–202337677	9420	155599	chr2:202334776–202335629	150	1.59	189	0.121	chr2:202335835–202337677	171	1.82	260	0.1671
	WNK1	chr12:1003802–1005236	12935	800572	chr12:1003802–1004326	30	0.23	39	0.005	chr12:1004363–1005236	33	0.26	49	0.0061
	WDR27	chr6:170060863–170062399	9937	128203	chr6:170060863–170061798	1322	13.30	2407	1.877	chr6:170061847–170062399	960	9.66	1533	1.1958
	CIP2A	chr3:108284302–108285343	9210	124822	chr3:108284302–108284744	126	1.37	181	0.145	Not Found	Not Found	0.00	Not Found	0.0000
	ITF57	chr3:107910491–107925474	12662	583056	chr3:107910491–107911322	64	0.51	150	0.026	chr3:107911374–107925474	68	0.54	157	0.0269
	HTT	chr4:3214437–3215684	11146	243427	chr4:3214437–3215348	452	4.06	599	0.246	chr4:3215464–3215684	738	6.62	1064	0.4371
	SKA2	chr17:57189707–57196679	10377	297301	chr17:57189707–57196756	373	3.59	605	0.203	Not Found	Not Found	0.00	Not Found	0.0000
	EVC	chr4:5735163–5743442	6716	74348	chr4:5735163–5743060	86	1.28	120	0.161	chr4:5743169–5743442	107	1.59	154	0.2071
	DYRK1A	chr21:38792687–38844985	10821	152058	chr21:38792687–38794883	29	0.27	51	0.034	chr21:38794955–38844985	11	0.10	15	0.0099
	GNAQ	chr9:80430687–80537076	10041	224120	chr9:80430687–80535563	23	0.23	28	0.012	chr9:80535619–80537076	325	3.24	810	0.3614
	ZMYM6	chr1:35485204–35485983	11692	199379	chr1:35485204–35485861	312	2.67	1041	0.522	chr1:35485881–35485983	413	3.53	1465	0.7348
	CYB5B	chr16:69482048–69492995	13834	1150919	chr16:69482048–69482509	191	1.38	286	0.025	chr16:69482657–69492995	16	0.12	19	0.0017
	MMS22L	chr6:97634567–97676769	8959	91164	chr6:97634567–97649237	41	0.46	58	0.064	chr6:97649343–97676769	128	1.43	185	0.2029
	MEMO1	chr2:32108532–32117060	8678	99228	chr2:32108532–32112103	167	1.92	230	0.232	chr2:32112157–32117060	1010	11.64	1589	1.6014
	PNISR	chr6:99864305–99873090	13184	888372	chr6:99864305–99868398	1	0.01	1	0.000	chr6:99868461–99873090	21	0.16	29	0.0033
Enriched	CACNA2D1	chr7:81695841–81714084	6256	96528	chr7:81695841–81705331	1	0.02	1	0.001	chr7:81705439–81713748	2	0.03	7	0.0073
	SSBP1	chr7:141438991–141441968	14501	2473164	chr7:141438991–141441109	38	0.26	71	0.003	chr7:141441260–141441968	41	0.28	60	0.0024
	DDX42	chr17:61882536–61883894	12718	722896	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
	ASAP1	chr8:131172211–131179781	11448	396871	chr8:131172211–131173030	2429	21.22	16818	4.238	chr8:131173040–131179781	2397	20.94	16510	4.1600
	DUXAP10	chr14:19884030–19894699	638	1502	Not Found	Not Found	0.00	Not Found	0.000	chr14:19893151–19894699	31	4.86	34	2.2636
	AVL9	chr7:32599077–32609631	11339	199392	chr7:32599077–32602169	2728	24.06	6204	3.111	chr7:32602526–32609631	811	7.15	1355	0.6796
	DYRK1A	chr21:38792687–38844985	10821	152058	chr21:38792687–38794883	29	0.27	51	0.034	chr21:38794955–38844985	11	0.10	15	0.0099
	FAM3A	chrX:153740736–153741146	9459	98652	chrX:153740736–153740891	351	3.71	481	0.488	chrX:153741031–153741146	1834	19.39	3467	3.5144
	FHOD3	chr18:34320802–34322699	7279	113308	chr18:34320802–34322339	210	2.89	295	0.260	chr18:34322432–34322699	170	2.34	216	0.1906
	TBCA*	chr5:77004173–77072028	14180	942768	NA	NA	NA	NA	NA	chr5:77070042–77072028	1306	9.21	4838	0.5132
	MZT1	chr13:73293236–73301661	12409	516948	chr13:73293236–73299779	51	0.41	103	0.020	chr13:73299917–73301661	51	0.41	79	0.0153
	LINC01296	chr14:19680686–19683691	239	315	chr14:19680686–19682236	20	8.37	22	6.984	chr14:19682353–19683691	1	0.42	1	0.3175
	SF3B3	chr16:70575738–70578340	12928	880623	chr16:70575738–70578071	233	1.80	467	0.053	chr16:70578153–70578340	174	1.35	273	0.0310
	SAFB	chr19:5654212–5654378	13168	1083231	Not Found	Not Found	0.00	Not Found	0.000	Not Found	Not Found	0.00	Not Found	0.0000
	GCFC2	chr2:75929550–75933648	11225	168121	chr2:75929550–75929816	124	1.10	195	0.116	chr2:75929934–75933648	534	4.76	697	0.4146
	MRPL45	chr17:36462599–36474585	12718	608565	chr17:36462599–36468549	778	6.12	1191	0.196	chr17:36468625–36474585	847	6.66	1292	0.2123
	SPIDR	chr8:48173584–48192449	10729	158491	chr8:48173584–48185928	414	3.86	568	0.358	chr8:48186043–48192449	708	6.60	1131	0.7136
	DUXAP8	chr14:19680686–19683691	239	315	chr14:19680686–19682236	20	8.37	22	6.984	chr14:19682353–19683691	1	0.42	1	0.3175
	PDXDC1	chr16:15102705–15103537	12939	767189	chr16:15102705–15103355	1472	11.38	3778	0.492	chr16:15103419–15103537	116	0.90	190	0.0248
	MAN1A2	chr1:117984948–118003110	11582	229559	chr1:117984948–117998706	427	3.69	914	0.398	chr1:117998829–118003110	40	0.35	57	0.0248
	RAF1	chr3:12641915–12645634	12808	832362	chr3:12641915–12644976	1841	14.37	4800	0.577	chr3:12645037–12645634	2187	17.08	5789	0.6955
	ERGIC3	chr20:34136619–34142142	4423	84287	chr20:34136619–34136916	2778	62.81	7045	8.358	chr20:34136962–34142142	194	4.39	922	1.0939

Columns (from left to right) indicate: 1. Exclusivity to LMI070 induction. 2. The gene ID containing the splicing events of interest. 3. The position of canonical splice junction (CJ). 4. The number of Intropolis RNA-seq datasets in which each canonical splice event was observed. 5. The total number of observations identified for each canonical splice site. 6. The position of junction 1 (J1) and the first LMI070-induced exon–exon junction (sorted by genomic position) connecting a canonical exon to a LMI070-induced pseudo exon. Columns 7 and 8 indicate the number and percentage of Intropolis datasets in which each J1 splice event was observed. Columns 9 and 10 indicate the number and percentage of total counts in which each J1 splice event was observed. 11. The position of junction 2 (J2) the second LMI070-induced exon–exon junction (sorted by genomic position) connecting a LMI070-induced pseudo exon to a canonical exon. Columns 12 and 13 list the number and percentage of Intropolis datasets in which the LMI070-induced splicing event was observed. Columns 14 and 15 indicate the total number and percentage of reads containing each junction in the Intropolis dataset.