Table I.
Clinical characteristics of study participants
| (Likely) damaging allele, n = 18 cases | (Likely) benign, n = 8 cases | VUS, n = 5 cases | No rare HNF1A allele variant, n = 916 cases | |
|---|---|---|---|---|
| Sex, male (n) | 5 | 4 | 2 | 529 |
| Age at recruitment (years) | 40 ± 17 | 48 ± 11 | 54 ± 14 | 47 ± 11 |
| Age at diagnosis (years) | 26 ± 9 | 36 ± 6 | 37 ± 10 | 35 ± 7 |
| Diabetes duration (years) | 13 ± 12 | 9 ± 7 | 17 ± 11 | 12 ± 10 |
| BMI (kg/m2) | 26 ± 5 | 35 ± 5 | 28 ± 6 | 31 ± 7 |
| hsCRP (mg/L) | 0.8 ± 1.3 | 5.2 ± 5.7 | 4.0 ± 6.3 | 6.2 ± 29.7 |
| HbA1c (%) | 7.7 ± 1.7 | 8.8 ± 2.1 | 6.7 ± 1.3 | 7.9 ± 2.7 |
| C-peptide (nmol/L) | 0.42 ± 0.21 | 0.81 ± 0.62 | 0.60 ± 0.57 | 5.11 ± 71.47 |
| Total cholesterol (mmol/L) | 4.75 ± 1.09 | 5.07 ± 0.88 | 4.74 ± 1.21 | 4.69 ± 1.23 |
| HDL (mmol/L) | 1.4 ± 0.3 | 1.1 ± 0.2 | 1.3 ± 0.4 | 1.3 ± 3.4 |
| Triglycerides (mmol/L) | 1.2 ± 0.5 | 2.0 ± 1.0 | 1.1 ± 0.3 | 2.0 ± 1.7 |
Mean values are presented for each group (±SD).
VUS: variants of unknown significance.