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. 2022 Mar 16;13:842921. doi: 10.3389/fphar.2022.842921

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Copyright © 2022 Chauzy, Akrong, Aranzana-Climent, Moreau, Prouvensier, Mirfendereski, Buyck, Couet and Marchand.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the final pharmacokinetic-pharmacodynamic model characterizing the inoculum effect of A. baumannii on PMB bactericidal activity (k_PMB). SC, subcutaneous; k_net, apparent growth rate constant of bacteria; k_slope, kill rate constant due to PMB; k_slope,med, kill rate constant for a theoretical starting inoculum of 6 log₁₀ CFU/thigh; k_inoc, constant describing the inoculum effect on k_slope; Cu, unbound PMB concentration; γ, power parameter for PMB effect.