TABLE 1.

Parameter estimates and relative standard errors for the final PK model.

Parameter	Unit	Estimate (%RSE)
Maximum absorption rate	mg/h/kg	14.7 (10.3)
Amount in the subcutaneous compartment that produces 50% of the maximum absorption rate	mg/kg	2.24 (41.4)
Clearance	L/h/kg	0.437 (3.9)
Distribution volume of the central compartment	L/kg	0.740 (16.7)
Distribution volume of the peripheral compartment	L/kg	0.743 (16.4)
Intercompartmental clearance	L/h/kg	0.315 (27.3)
Fraction unbound	-	0.166 (9.3)
Proportional residual error for total concentrations	%	24 (11.4)
Additive residual error for total concentrations	mg/L	0.0115 (40.6)
Proportional residual error for unbound concentrations	%	35 (14.7)
Additive residual error for unbound concentrations	mg/L	0.0457 (36.8)

RSE, Relative Standard Error