TABLE 2.
Parameter estimates and relative standard errors (RSE) for the final PMB PKPD model.
| Parameter | Unit | Estimate (%RSE) |
|---|---|---|
| knet: Apparent growth rate constant | h−1 | 0.594 (16.6) |
| Bmax: Maximum bacterial count reached in the tissue | Log10 CFU/thigh | 8.00 (2.0) |
| kslope,med: Kill rate constant due to PMB for a theoretical median starting inoculum of 6.5 log10 CFU/thigh | L/mg.h | 1.00 (12.1) |
| γ: Power parameter for PMB effect | - | 0.162 (20.1) |
| kinoc: Constant describing the inoculum effect on kslope,med | - | −0.194 (22.3) |
| σ: Additive residual error on the log10 scale for total bacterial count | Log10 CFU/thigh | 1.63 (9.4) |