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. 2022 Mar 16;13:841410. doi: 10.3389/fphar.2022.841410

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Copyright © 2022 Li, Lei, Yang, Zhao, Hou, Wang, Tang, Li and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of AKT inhibitor on myocardial ferroptosis with propofol pretreatment. (A–F): Effect of propofol on I/R-induced myocardial MDA, iron, and antioxidant enzymes expressions. (G–H): GSH/GSSG ratio and iron changes in the myocardium. (I) Structural changes in myocardial fibers based on HE staining. Scale bar: 100 μm. (J) Mitochondrial changes under electron microscopy. Scale bar: 10 μm. (K–M): Expression of p53 and p-p53 in myocardium based on the western blot assay. N = 6. Data are expressed as the mean ± SD. Significance was calculated using one-way ANOVA with Tukey’s post hoc test or the t-test. p-values < 0.05 were considered statistically significant. *p < 0.05, **p < 0.01, ***p < 0.001.