Table 3.
BMD associated microbial metabolic pathways.
| MetaCyc ID | Pathway | ρadj | P-value |
|---|---|---|---|
| PWY-5941 | Glycogen degradation II | 0.13 | 0.005 |
| PWY-5181 | Toluene degradation III (via p-cresol) | 0.13 | 0.006 |
| PWY-6185 | 4-methylcatechol degradation | 0.12 | 0.006 |
| PWY-5695 | Urate biosynthesis | –0.11 | 0.011 |
| CATECHOL-ORTHO-CLEAVAGE-PWY | Catechol degradation to β-ketoadipate | 0.11 | 0.012 |
| PWY-5417 | Catechol degradation III | 0.11 | 0.012 |
| PWY-5659 | GDP-mannose biosynthesis | 0.11 | 0.013 |
| CRNFORCAT-PWY | Creatinine degradation I | 0.10 | 0.021 |
| GLYCOGENSYNTH-PWY | Glycogen biosynthesis I (from ADP-D-Glucose) | 0.10 | 0.023 |
| PWY-6182 | Superpathway of salicylate degradation | 0.10 | 0.024 |
| GALACTUROCAT-PWY | D-galacturonate degradation I | 0.10 | 0.026 |
| PWY-1861 | Formaldehyde assimilation II | 0.10 | 0.030 |
| PWY-3841 | Folate transformations II | –0.10 | 0.032 |
| HOMOSER-METSYN-PWY | L-methionine biosynthesis I | 0.09 | 0.037 |
| PWY-7374 | 1,4-dihydroxy-6-naphthoate biosynthesis I | –0.09 | 0.037 |
| 1CMET2-PWY | N10-formyl-tetrahydrofolate biosynthesis | –0.09 | 0.038 |
| PWY-6703 | PreQ0 biosynthesis | –0.09 | 0.040 |
| ARGININE-SYN4-PWY | L-ornithine de novo biosynthesis | –0.09 | 0.040 |
| P124-PWY | Bifidobacterium shunt | 0.09 | 0.042 |
| PWY-5347 | Superpathway of L-methionine biosynthesis | 0.09 | 0.042 |
| CITRULBIO-PWY | L-citrulline biosynthesis | –0.09 | 0.043 |
| METSYN-PWY | L-homoserine and L-methionine biosynthesis | 0.09 | 0.043 |
ρadj denoted partial Speraman correlation coefficient with adjustment for age, BMI, exercise, years since menopause, FSH, and estradiol.