Table 3.
Functional enrichment in predicted protein network (STRING).
| Local Network Cluster (STRING) | ||||
|---|---|---|---|---|
| Cluster | Description | Count in network | Strength | False discovery rate |
| CL-6642 | mixed, incl. zinc-finger domain, and ETC complex I subunit consensus | 6 of 8 | 2.57 | 1.90e-12 |
| CL-6638 | Oxidative phosphorylation | 8 of 13 | 2.48 | 7.16e-16 |
| CL-6668 | mixed, incl. Translocase, and 4Fe-4S binding domain | 3 of 6 | 2.39 | 8.24e-06 |
| CL-6636 | Oxidative phosphorylation | 11 of 25 | 2.34 | 3.76e-20 |
| CL-6630 | Oxidative phosphorylation and porin, eukaryotic type | 12 of 67 | 1.95 | 2.16e-18 |
| CL-8320 | mixed, incl. Protein transport, and Pleckstrin homology domain. | 3 of 148 | 1 | 3.83e-02 |
| KEGG Pathways | ||||
| Pathway | Description | Count in network | strength | False discovery rate |
| tut00190 | Oxidative phosphorylation | 10 of 80 | 1.79 | 1.11e-14 |
| tut04144 | Endocytosis | 3 0f 116 | 1.11 | 0.0042 |
| tut01100 | Metabolic pathways | 12 of 810 | 0.86 | 1.46e-07 |
| Annotated Keywords (Uniprot) | ||||
| Keyword | Description | Count in network | Strength | False discovery rate |
| KW-0342 | GTP-binding | 3 of 74 | 1.3 | 0.007 |
| KW-0813 | Transport | 5 of 358 | 0.84 | 0.0197 |
| Protein Domains (Pfam) | ||||
| Domain | Description | Count in network | Strength | False discovery rate |
| PF05347 | Complex 1 protein (LYR family) | 2 of 6 | 2.22 | 0.007 |
| PF00350 | Dynamin family | 2 of 8 | 2.09 | 0.007 |
| PF00153 | Mitochondrial carrier protein | 2 of 40 | 1.39 | 0.0343 |
| PF00520 | Ion transport protein | 2 of 43 | 1.36 | 0.0343 |
| PF08477 | Ras of Complex, Roc. Domain of DAPkinase | 3 of 71 | 1.32 | 0.0091 |
| PF00025 | ADP-ribosylation factor family | 3 of 70 | 1.32 | 0.0091 |
| PF00071 | Ras family | 3 of 79 | 1.27 | 0.0091 |
| Protein Domains and Features (InterPro) | ||||
| Domain | Description | Count in network | Strength | False discovery rate |
| IPR030381 | Dynamin-type guanine nucleotide-binding (G) domain | 2 of 5 | 2.29 | 0.0098 |
| IPR008011 | Complex 1 LYR protein | 2 of 6 | 2.22 | 0.0098 |
| IPR022812 | Dynamin superfamily | 2 of 7 | 2.15 | 0.0098 |
| IPR020849 | Small GTPase superfamily, Ras-type | 2 of 18 | 1.74 | 0.0145 |
| IPR002067 | Mitochondrial carrier protein | 2 of 18 | 1.74 | 0.0145 |
| IPR005821 | Ion transport domain | 2 of 31 | 1.5 | 0.0264 |
| IPR023395 | Mitochondrial carrier domain superfamily | 2 of 36 | 1.44 | 0.0314 |
| IPR018108 | Mitochondrial substrate/solute carrier | 2 of 36 | 1.44 | 0.0314 |
| IPR001806 | Small GTPase | 3 of 60 | 1.39 | 0.0098 |
| IPR005225 | Small GTP-binding protein domain | 3 of 79 | 1.27 | 0.0142 |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase | 6 of 557 | 0.72 | 0.0145 |
| Protein Domains (SMART) | ||||
| Domain | Description | Count in network | Strength | False discovery rate |
| SM00173 | Ras subfamily of RAS small GTPases | 2 of 8 | 2.09 | 0.0034 |