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. 2022 Mar 16;13:859241. doi: 10.3389/fmicb.2022.859241

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Copyright © 2022 Huang, Zhang, Bible, Liang, Zheng, Wang, Hao and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synchronous temporal changes between variant-specific FTMs and variant prevalence. (A) Weekly distribution of SARS-CoV-2 genome sequences according to sampling time. (B) Time course of major variant distribution in collected sequences. (C) A Wald’s linkage hierarchical cluster tree of frequency trajectories of mutations. One hundred and fifty-eight mutations passing filtration were analyzed, annotated and displayed. Variant-specific mutations were flagged.